Solution
from flask import Flask
import uuid
...
uuid_to_email = {}
...
@app.route('/')
def index():
user_id = str(uuid.uuid4())
uuid_to_email[user_id] = request.headers.get('X-MS-CLIENT-PRINCIPAL-NAME')
return render_template('index.html', uuid=user_id) # where it is implied that you would then use the uuid in the client-side code to story it and pass it back to the endpoints you want to do that with