Solution
if __name__ == '__main__':
socketio.run(app, host="0.0.0.0", port="80", debug=True,
certfile='cert.pem', keyfile='key.pem',
server_side=True)
if __name__ == '__main__':
socketio.run(app, host="0.0.0.0", port="80", debug=True,
certfile='cert.pem', keyfile='key.pem',
server_side=True)